Species affected: Mainly chickens, serotype 2 also occurs in turkeys and ducks. Age affected: Causes: Infectious bursal disease virus is a birnavirus. It is highly . Infectious bursal disease – Immunosuppression – Pathotype – Vaccination. Summary. Introduction in the sector over the sanitary status of poultry. Gumboro. In all poultry producing regions of the world, infectious bursal disease virus (IBDV ) continues to be a major constraint for poultry farmers.

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Also, diarrhoea, anorexia, depression, ruffled feathers, especially in the region of the head and the neck are gimboro. The consequences of immunosuppression associated with IBDV are vaccination failure and susceptibility of chickens to opportunistic pathogens.

The birnavirus crystal structure reveals structural relationships among icosahedral viruses. The grossly atrophied bursa s exhibited the fibrosis in between the djsease follicles as evidenced by the fibrous tracts running between them Figure-3 that was evidenced by pseudolobulation in histopathological examination. Infectious bursal disease; pp. VP3 also interacts extensively with the viral dsRNA genome.

However, there are no indications of vertical transmission.

Evaluation of modified vaccinia virus Ankara expressing VP2 protein of infectious bursal disease virus as an immunogen in chickens. IBD virus has a lymphocidic effect and the most severe injuries are in the lymph follicles of the bursa of Fabricius. Events Latest Events Submit Event.

This response is mediated by pattern recognition receptors PRRswhich detect pathogen-associated molecular patterns PAMPs for induction of effector molecules. This immunohistopathological scoring was done using the scoring scale ofas applied by Oladele et al. Clinico-pathological studies on natural and experimental infectious bursal disease in broiler chickens. Infectious bursal disease-like virus in cases of transmissible viral proventriculitis.

Synthetic transcripts of double-stranded Birnavirus genome are infectious. The potential for economic losses in the poultry industry also exists when anytime a new antigenic or pathogenic strain of IBDV is introduced into a country or geographic region [ 10 ]. The genetic basis for the antigenicity of the VP2 protein of the infectious bursal disease virus.

It is concluded that IHC staining is a precise, specific, rapid, and reliable method to demonstrate the IBDV antigen in the altered tissues due to IBDV infection, which is in concurrence with gross or microscopic lesions and supplemented by immunofluorescent technique.


Peri-focal vaccination may not be effective for the combat of an outbreak, due to the rapidity of wild-IBDV spreading. DNA-mediated vaccination conferring protection against infectious bursal disease in broiler chickens in the presence of maternal antibody.

Collection and processing of samples A total of six poultry farms were visited in and around the areas of Ludhiana and the other districts of Punjab, as shown in Table Phylogenetic evidence for homologous recombination within the family Birnaviridae. Thus, regular vaccination and adoption of proper prophylactic measures are mandatory to diminish the occurance of this disease.

The virus is highly resistant to most disinfectants and environmental onditions. In the acute form birds are prostrated, debilitated and dehydrated. Immunohistopathology The affected bursal sections revealed viral antigens in the lesion sites identified in tissue sections, especially inside the cells in the rarefied areas of bursal follicles along with the inner lining of the cystic cavities in affected follicles.

Delayed vaccine virus replication in chickens vaccinated subcutaneously with an immune complex infectious bursal disease vaccine: In various previous experimental studies, IBDV antigens have been detected in macrophages within follicles, the interstitium, and the lymphoid cells of bursa of Fabricius, e. The characteristic gross lesions of the disease include dehydration of the muscles with ecchymotic hemorrhages, enlargement, and orange discoloration of kidneys. About About 5m Publishing Our Editors.

The innate immune response is pkultry first-line of defense against pathogens in vertebrate species. In some cases, the bursa is filled with coagulated fibrinous exudate that usually forms casts with the shape of mucosal folds. Statistical analysis The Graphpad Prism software was employed to statistically ascertain the relationship between the histopathological changes in the bursas from affected birds and the immunohistopathological scoring of the histopathologically positive samples.

It is worth to mention here that the stress was put on considering only the representative samples from each outbreak, although the number of the birds affected was more. Besides biosecurity, vaccination is the most important measure to control IBDV in the field. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.


Infectious bursal disease virus in poultry: current status and future prospects

Comparison of agar gel immunodiffusion test, immunohistochemsitry and reverse transcription – Polymerase chain reaction for detection of infectious bursal disease virus.

Development and large-scale use of recombinant VP2 vaccine for the prevention of infectious bursal disease of chickens. Immunosuppression of very young chickens, less than three weeks of age, is possibly the most important outcome and may not be clinically detectable subclinical.

The presence of viral antigen was also appreciated in the bursal interfollicular connective tissue Figure-5 as well as the bursal epithelium which was also reported by Oladele et al. The diagnosis could be confirmed by detection of typical gross lesions throughout a patho-anatomical study.

Abstract Fulltext Metrics Get Permission. As the viral capsid protein, VP2 carries immunodominant epitopes responsible for the induction of a protective humoral immune response.

INFECTIOUS BURSAL DISEASE (GUMBORO) – Diseases of Poultry – The Poultry Site

Molecular evidence for a geographically restricted population of infectious bursal disease viruses. Effective protection by high efficiency bicistronic DNA vaccine against infectious bursal disease virus expressing VP2 protein gumbor chicken IL This work is published and licensed by Dove Medical Press Limited.

Biosecurity with adequate restriction to farm visitation and distancing from other flocks. However, the B-cell destruction is usually most severe in subclinically infected young, as virus will destroy a smaller population and most cells in one place the bursa. Sequence and phylogenetic analysis of a Chinese very virulent infectious bursal disease virus. A complex host —Pathogen interaction.

Published online Dksease Tissue culture infectivity of different strains of infectious bursal disease virus is determined by distinct amino acids in VP2. Overall histopathological scoring and the IHC scoring, as per Oladele fisease al. The lungs here showed the infiltrative changes in the parabronchi leading to its thickening.